Our unique scientific approach

Led by Professor Philip Hodgkin and Dr Vanessa Bryant.

This program seeks to identify the essential cellular processes that govern how the immune system senses and responds to challenges. By examining variations in these immune parameters, or ‘dials’, and linking them to immune dysfunction in patients with diverse immune-related diseases, we aim to develop reliable blood tests that measure immune cell health with precision.

Led by Professor Daniel Gray and Professor Stephen Nutt.

This program focuses on creating comprehensive models of immune processes that connect response dynamics to their underlying molecular mechanisms. By establishing how these mechanisms operate in different tissues or disease-settings, we can develop simulations of individual immune systems and predict the effects of various drugs.

Led by Dr Vanessa Bryant and Dr Charlotte Slade.

This program integrates immune health data, including immune health “dials”, genetic variation, and cellular and multi-omic profiles, with detailed clinical information from key patient groups. By tracking immune function and treatment responses over time, we aim to identify measurable indicators that predict disease progression and therapeutic outcomes, ultimately supporting more personalised and effective care.

The Snow Centre is developing new assays to identify molecular and cellular biomarkers of disease activity.

These tools will enhance diagnostic precision, help identify people at higher risk of poor outcomes, and support biologically informed treatment choices, ultimately improving monitoring, treatment effectiveness and patient outcomes.

By integrating molecular ‘omic and immune profiling data through advanced computational modelling, the centre aims to predict how individual patients will respond to therapies.

This personalised approach will reduce trial-and-error in treatment selection, speed up access to effective therapies and improve overall care.

The Snow Centre is committed to cultivating the next generation of leaders in immune health through dedicated training, mentorship and cross-disciplinary collaboration.

Researchers and clinicians at the Snow Centre are immersed in a rich systems immunology environment, gaining hands on experience with cutting-edge technologies, computational modelling, and translational science. This environment fosters rapid integration of research findings into clinical decision-making.

The centre supports a multidisciplinary PhD program designed that brings together trainees from immunology, genomics, clinical medicine, bioinformatics and data science. By embedding students within collaborative teams across lab and clinic, the program equips early-career researchers with the skills and knowledge to bridge the gap between discovery and patient care.

Through this investment in people, the centre is building national capacity and driving a culture of innovation and interdisciplinary excellence in immune-related research and medicine.

The Snow Centre for Immune Health is poised to expand its research into new disease areas and broader patient cohorts. By investigating a wider range of conditions and incorporating more diverse populations, the Centre will explore how immune system dynamics vary across different health states, life stages, and genetic backgrounds, ensuring discoveries are applicable to real-world populations.

To support this expansion, the Centre will embrace artificial intelligence (AI) and machine learning (ML) technologies to elevate data analysis and interpretation. These tools will help uncover complex, previously hidden patterns in large datasets, accelerating biomarker discovery, refining predictive models and improving the precision of patient stratification.

The centre will also strengthen its impact through strategic partnerships with global research networks. These collaborations will facilitate knowledge exchange, provide access to diverse and underrepresented patient groups, and accelerate the translation of research into clinical practice. Through global collaboration, the Centre aims to fast-track the translation of new discoveries into immune-based therapies and extend the reach of personalised immune care across diverse populations.